Ras Downstream Effector GGCT Alleviates Oncogenic Stress

Ras Downstream Effector GGCT Alleviates Oncogenic Stress

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Summary: How cells adapt to oncogenic transformation-associated cellular stress and become fully transformed is still unknown.Here we identified a novel GGCT-regulated glutathione (GSH)-reactive oxygen species (ROS) metabolic pathway in oncogenic stress alleviation.We identified GGCT as a target of oncogenic Ras and that it is required for oncogenic Ras-induced primary mouse cell proliferation and transformation caruso rhodiola and in vivo lung cancer formation in the LSL-Kras G12D mouse model.

However, GGCT deficiency is compatible with normal mouse development, suggesting that GGCT can be a cancer-specific therapeutic target.Genetically amplified GGCT locus helen dale samson further supports the oncogenic driving function of GGCT.In summary, our study not only identifies an oncogenic function of GGCT but also identifies a novel regulator of GSH metabolism, with implications for further understanding of oncogenic stress and cancer treatment.

: Biological Sciences; Cell Biology; Cancer Subject Areas: Biological Sciences, Cell Biology, Cancer.